Profile

After earning his medical degree from the University of Montreal, Dr. Dupuis completed his internship at McGill University, followed by another doctorate in Experimental Medicine at the same institution. He subsequently specialized in Internal Medicine and then in Cardiology at the University of Sherbrooke. Since 1994, he has practiced as a cardiologist at the Montreal Heart Institute, where he established a laboratory for both fundamental and applied research. Dr. Dupuis has climbed through all levels of the Fonds de recherche en santé du Québec (FRQS) career researcher program and was awarded a National Researcher Scholarship.

Dr. Dupuis’s research focuses on the study of pulmonary circulation and its alterations in pulmonary hypertension. The goal of his research is to understand the pathophysiological mechanisms underlying the disease and to develop innovative diagnostic and therapeutic approaches. Since 2008, he has been working on the development of novel patented molecules for molecular imaging of the pulmonary circulation, as well as new therapies targeting pulmonary hypertension, particularly in association with heart failure.

Additionally, Dr. Dupuis is the director of the Pulmonary Vascular Diseases Research Group (MVP), which he founded in the spring of 2017. This group aims to develop new treatments and diagnostic procedures for Group II pulmonary hypertension. Since its inception, numerous innovative clinical and preclinical projects have emerged, involving over 20 researchers from various clinical and fundamental disciplines.

Research Interests

•Pathophysiology and treatments of pulmonary vascular diseases

Research Projects

•Molecular imaging of pulmonary vascular diseases

Awards and Distinctions

•2018-2021: NSFC-FRQS Cardiovascular Research Grant

•2017: Investigator Award, Pulmonary Vascular Research Institute

•2015-2017: Merck Sharp & Dohme Corp. Fund Award, University of Montreal

•2013-2016: Grant from the Quebec Consortium for Drug Discovery (CQDM)

•2005-2010: National Researcher Scholarship, FRQS

•2008: Canadian Pfizer Cardiovascular Research Award for the study on atorvastatin and lung structural remodeling in heart failure

•2000: Carsley Award for Research Excellence, Montreal Heart Institute

•1999: Martial G. Bourassa Award for Excellence in Clinical Research, Montreal Heart Institute

•1999: Best Scientific Presentation Award, The Lancet Conference

•1993: Merck Frosst Scholarship, Quebec Association of Cardiologists

•1991: Knoll Young Investigator Scholarship, Quebec Association of Cardiologists

•1989: Award of Excellence for Best Canadian Young Researcher at the 17th French-Speaking Cardiology Congress

•1989: Young Investigator Award, Canadian Cardiovascular Society, 42nd Annual Meeting, Vancouver, British Columbia

Key Publications

1.Harel F, Nguyen QT, Nsaibia MJ, et al. SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer. Respiratory Research. 2021; 22(1):240.

DOI: 10.1186/s12931-021-01836-3

2.Nguyen QT, Nsaibia MJ, Sirois MG, et al. PBI-4050 reduces pulmonary hypertension, lung fibrosis, and right ventricular dysfunction in heart failure. Cardiovascular Research. 2020; 116(1):171-82.

DOI: 10.1093/cvr/cvz034

3.Alonso Martinez LM, Harel F, Nguyen QT, et al. Al[(18)F]F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation. Nuclear Medicine and Biology. 2018; 67:36-42.

DOI: 10.1016/j.nucmedbio.2018.10.003

Profiles:

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